Kamaitachi Yamauchi also tried it and lost 8 kg in 3 months.

The Japan Diabetes Society issued a statement titled “The Japan Diabetes Society’s Position on Off-Label Use of GLP-1 Receptor Agonists and GIP/GLP-1 Receptor Agonists” to its members in April of this year (a similar statement was also issued in July 2020), and has issued repeated warnings since. However, the problem of limited shipments of the GLP-1 receptor agonists Ozempic and Torricity, as well as the GIP/GLP-1 receptor agonist Manjaro, has not been resolved.

What is scary about the off-label use is the high possibility that physicians in other departments who are not specialists in diabetes and metabolic medicine are prescribing these drugs for profit. The Japan Diabetes Society warns that “the safety and efficacy in Japanese people without type 2 diabetes have not been confirmed.

While it has long been reported that the use of GLP-1 for diabetes increases the risk of gastrointestinal adverse events such as biliary tract disease, pancreatitis, intestinal obstruction, and gastric insufficiency paralysis, a study from the University of British Columbia in Canada found an even greater risk when used in healthy humans, JAMA (October 5, 2009 online edition) reported that the risk of pancreatitis increases 9-fold, bowel obstruction 4.2-fold, and gastric insufficiency paralysis 3.67-fold.

Pancreatitis can be acute or chronic, but it is acute pancreatitis that is caused by GLP-1. The pancreas becomes swollen and swollen, and when the inflammation is strong, blood flow to the pancreas is impaired, resulting in tissue necrosis. In addition, the digestive enzymes produced in the pancreas digest their own pancreas and surrounding tissues through autolysis, which is accompanied by sudden and severe abdominal pain never experienced before, and in severe cases, death is possible.

In addition, if used by people with normal blood sugar, it can cause hypoglycemia and even fainting, and if a young woman is too thin, it increases her susceptibility to infection and risk of infertility. Moreover, if people are able to lose more and more weight by simply taking medicine without the attention of a doctor, some will continue to lose weight without restraint.

Dr. Masaya Sakamoto of the Department of Diabetes and Endocrinology, International University of Health and Welfare, Mita Hospital, is concerned.

The Ms. A in the beginning of this article received an injection despite her worries, and after taking the medication over the next three days, she was able to lose two kilograms in no time. However, he stopped continuing the program because he experienced symptoms such as nausea and general lethargy. It may seem appealing to lose weight effortlessly, but he made the mature decision that it would be a waste of time and energy if he destroyed his health.