A Dream Drug That Eases Pregnancy Anxiety!　Doctor Explains Risks of Morning Sickness Drug Bonjesta

The Nature of Morning Sickness

Morning sickness is a common problem that plagues many women in the early stages of pregnancy. In recent years, attention has focused on Bonjesta, a morning sickness treatment used in the United States. Although the drug has not yet been certified in Japan, some clinics offer it as a free treatment, and there are many posts on social networking sites from people who have actually used it.

I was able to get through my pregnancy because of this.

“It helped me get over my pregnancy,” “It made my morning sickness anxiety disappear at once.

On the other hand, some people praised the clinic, saying, “It helped me get through my pregnancy,

“It’s scary that people talk about it like it’s a panacea.

“It’s scary that people talk about it like it’s a panacea,” and “Will it have any effect on the baby?

On the other hand, there are those who are concerned about the effects on the baby. Is BonJesta really a dream drug that will relieve the anxiety of morning sickness? Dr. Kenichiro Sakaguchi, director of Sangenjaya Art Clinic, explains in detail the true nature of morning sickness, the mechanism of action of the morning sickness medication, and its risks.

Morning sickness is not a disease,” he says, “It’s a path we all have to go through. Many expectant mothers are told that morning sickness is not a disease and that everyone goes through it. However, Dr. Sakaguchi clearly denies this.

Morning sickness is a physiological reaction to the rapid changes that occur in the body during the early stages of pregnancy. The background of morning sickness is a complex combination of the following three factors.

Hormonal changes
Pregnancy causes a rapid increase in the pregnancy hormone hCG, which is essential for maintaining pregnancy. hCG stimulates the corpus luteum in the ovaries, which in turn stimulates the secretion of the female hormone progesterone (luteinizing hormone). While progesterone stabilizes pregnancy by maintaining the endometrium and suppressing uterine contractions, it also slows gastrointestinal motility. This can lead to gastric distress and nausea.

● Blood sugar fluctuations
In early pregnancy, blood glucose levels tend to drop during fasting. If the patient is unable to eat due to morning sickness, blood glucose levels drop further and nausea intensifies. This vicious cycle of feeling sick and not being able to eat worsens, and as a result, the patient is likely to become unable to eat again.

Disturbance of the autonomic nervous system
In the early stages of pregnancy, the autonomic nervous system becomes hypersensitive due to rapid changes in the body. This effect is worse the moment you wake up in the morning or when you are nervous.

Coming to the Japanese market within 5 years!

How does the controversial Bonjesta work for morning sickness?

Bonjesta is an oral medication that combines two ingredients: doxylamine succinate (an antihistamine) and pyridoxine hydrochloride (vitamin B6).

Doxylamine acts on the vomiting center and histamine receptors in the brain to relieve nausea signals. Vitamin B6 is involved in the balance of neurotransmitters and is believed to work in the direction of reducing the feeling of nausea.

A slight reduction in nausea can help break the vicious cycle of morning sickness by allowing you to eat and drink more fluids. However, the effects vary greatly from person to person, and the drug does not work the same way for everyone.”

Is there any risk associated with Bonjesta?

At this point, we have no data to conclude that there is a clear increased risk of fetal malformations. It has been used overseas for many years.

However, Dr. Sakaguchi is adamant.

That does not mean that it is absolutely safe. It just means that at this point, there is no data to conclude that the risk is increased. We must not forget that the early stages of pregnancy are the most sensitive period, when the baby’s vital organs are being formed.

Side effects that may occur in those who take the drug Known side effects include drowsiness, dizziness, and dry mouth, and the drug is particularly prone to drowsiness. Driving should be avoided after taking the drug.

Dr. Sakaguchi continued.

The biggest risk is that you get your hopes up too high. If you think, ‘If I take this, morning sickness will go away,’ or ‘I won’t be anxious about pregnancy,’ you will be driven into a mental corner if it doesn’t work. Remember, this is not a drug that will cure morning sickness, but a drug that will gradually break the vicious cycle by making you feel less morning sickness.”

Morning sickness is a complex reaction involving hormones, blood sugar, and the autonomic nervous system. No single drug can solve all of them.

Mochida Pharmaceutical announced that it has signed an agreement with Canadian company Duchenay to develop and market Bonjesta in Japan, with the aim of bringing the drug to the Japanese market by 2030.

Dr. Sakaguchi sounds a warning.

Dr. Sakaguchi warned, “The move toward approval is a big step in itself, but it will take time until approval is granted. However, it will take time until approval, and in the meantime, it will remain an unapproved drug.

Currently, the use of Bonjesta in Japan takes the form of free medical treatment or private medical treatment. Some people say through social networking services and online medical care that morning sickness will soon lessen, but I feel that this is an overstatement.

In the future, there is a possibility that Bonjesta will become a standard option in Japan.

However, morning sickness is a sign that the body is desperately trying to adjust to the big task of pregnancy. Rather than putting too much hope in medicine, it is a realistic option to overcome the early stages of pregnancy with proper understanding and medical support.